Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G‐Quadruplexes
نویسندگان
چکیده
The synthesis and characterization of a small series cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind G-quadruplexes from both telomeric oncogene promoter sequences. Some them exhibited high affinity effective G-quadruplex-stabilizing properties. Overall, these may represent useful leads developing more potent selective analogues.
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2022
ISSN: ['1434-193X', '1099-0690']
DOI: https://doi.org/10.1002/ejoc.202200718